Ikuo Hirano Selected Research

Eosinophilic Esophagitis

11/2022	Fluticasone Propionate Orally Disintegrating Tablet (APT-1011) for Eosinophilic Esophagitis: Randomized Controlled Trial.
1/2022	Budesonide Oral Suspension Improves Outcomes in Patients With Eosinophilic Esophagitis: Results from a Phase 3 Trial.
1/2022	A Clinical Severity Index for Eosinophilic Esophagitis: Development, Consensus, and Future Directions.
1/2022	Long-Term Treatment of Eosinophilic Esophagitis With Budesonide Oral Suspension.
1/2022	A Clinical Severity Index for Eosinophilic Esophagitis: Development, Consensus, and Future Directions.
12/2021	Effectiveness and Safety of High- vs Low-Dose Swallowed Topical Steroids for Maintenance Treatment of Eosinophilic Esophagitis: A Multicenter Observational Study.
1/2021	Type 2 Immunity and Age Modify Gene Expression of Coronavirus-induced Disease 2019 Receptors in Eosinophilic Gastrointestinal Disorders.
1/2021	Improvements in Dysphagia and Pain With Swallowing in Patients With Eosinophilic Esophagitis Receiving Budesonide Oral Suspension.
1/2021	Long-term Efficacy and Tolerability of RPC4046 in an Open-Label Extension Trial of Patients With Eosinophilic Esophagitis.
1/2021	Eosinophilic Esophagitis: Etiology and Therapy.

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Ikuo Hirano Research Topics

Disease

44	Eosinophilic Esophagitis 11/2022 - 01/2011
14	Eosinophilia 01/2020 - 06/2007
13	Gastroesophageal Reflux (GERD) 08/2017 - 08/2004
10	Deglutition Disorders (Dysphagia) 11/2022 - 05/2004
8	Hypoxia (Hypoxemia) 01/2022 - 01/2011
7	Inflammation (Inflammations) 01/2021 - 07/2011
6	Anemia 01/2022 - 01/2011
6	Esophageal Achalasia (Megaesophagus) 03/2017 - 12/2003
3	Eosinophilic enteropathy 01/2021 - 01/2020
3	Esophageal Diseases 03/2017 - 03/2013
3	Hypersensitivity (Allergy) 09/2013 - 07/2011
2	Asthma (Bronchial Asthma) 01/2020 - 09/2013
2	Disease Progression 01/2020 - 08/2011
2	Gastrointestinal Diseases (Functional Gastrointestinal Disorders) 01/2018 - 01/2017
2	Systemic Scleroderma (Systemic Sclerosis) 01/2017 - 08/2011
2	Food Hypersensitivity (Food Allergy) 04/2016 - 01/2016
2	Esophagitis 07/2015 - 08/2012
1	Candidiasis (Moniliasis) 11/2022
1	Hepatocellular Carcinoma (Hepatoma) 01/2022
1	Pain (Aches) 01/2021
1	Duodenitis 10/2020
1	Adrenal Insufficiency (Adrenal Gland Hypofunction) 01/2020
1	Atopic Dermatitis (Atopic Eczema) 01/2020
1	Infections 10/2019
1	Barrett Esophagus (Barrett's Esophagus) 01/2018
1	Polycythemia (Erythrocytosis) 08/2015
1	Confusion (Bewilderment) 07/2015
1	Fibrosis (Cirrhosis) 10/2013
1	Pathologic Constriction (Stenosis) 08/2012
1	Bile Reflux 11/2006
1	Intussusception 03/2006

Drug/Important Bio-Agent (IBA)

11	Proton Pump InhibitorsIBA 01/2021 - 03/2007
10	Erythropoietin FDA Link 01/2022 - 01/2011
9	SteroidsIBA 11/2022 - 05/2011
8	AcidsIBA 01/2018 - 12/2003
7	Budesonide (Pulmicort)FDA LinkGeneric 01/2022 - 01/2017
7	AntigensIBA 01/2021 - 07/2011
6	SuspensionsIBA 01/2022 - 01/2017
5	Adrenal Cortex Hormones (Corticosteroids)IBA 12/2021 - 09/2013
5	Phenobarbital (Luminal)FDA Link 10/2021 - 08/2010
4	Biomarkers (Surrogate Marker)IBA 01/2020 - 07/2015
3	Intercellular Signaling Peptides and Proteins (Growth Factors)IBA 01/2022 - 01/2019
3	Interleukin-13IBA 01/2021 - 01/2018
3	Proton Pumps (Proton Pump)IBA 01/2015 - 08/2012
2	APT-1011IBA 11/2022 - 01/2020
2	TabletsIBA 11/2022 - 01/2020
2	cendakimabIBA 01/2021 - 01/2019
2	Monoclonal AntibodiesIBA 01/2021 - 01/2019
2	AllergensIBA 01/2020 - 07/2013
2	Biological ProductsIBA 01/2020 - 03/2016
2	Pharmaceutical PreparationsIBA 01/2019 - 08/2017
2	acceleratory factor from growth hormone (AcG)IBA 05/2013 - 03/2007
1	Fluticasone (Cutivate)FDA LinkGeneric 11/2022
1	roxadustatIBA 01/2022
1	ProdrugsIBA 01/2022
1	RNA (Ribonucleic Acid)IBA 01/2021
1	AK002IBA 10/2020
1	Hydrocortisone (Cortisol)FDA LinkGeneric 01/2020
1	dupilumabIBA 01/2020
1	BariumIBA 04/2018
1	Mitoxantrone (Novantrone)FDA LinkGeneric 11/2017
1	Prolyl Hydroxylases (Prolyl Hydroxylase)IBA 02/2016
1	Transcription Factors (Transcription Factor)IBA 08/2015
1	Protein Isoforms (Isoforms)IBA 08/2015
1	Oxygen (Dioxygen)IBA 08/2015
1	AutoantibodiesIBA 07/2015
1	Transforming Growth Factors (Transforming Growth Factor)IBA 05/2014
1	CytokinesIBA 05/2014
1	Contrast MediaIBA 01/2014
1	Leukotriene Antagonists (Leukotriene Receptor Antagonists)IBA 09/2013
1	Immunologic Factors (Immunomodulators)IBA 09/2013
1	Angiotensin Receptor AntagonistsIBA 09/2013
1	Cyclophosphamide (Cytoxan)FDA LinkGeneric 08/2011
1	tetrachloroisophthalonitrile (Bravo)IBA 08/2004

Therapy/Procedure

24	Therapeutics 01/2022 - 11/2006
5	Myotomy 03/2015 - 05/2004
3	Diet Therapy (Therapy, Diet) 01/2020 - 07/2013
2	Ambulatory Care (Outpatient Care) 01/2022 - 01/2022
2	Heller Myotomy 03/2015 - 12/2014
1	Immunomodulation 10/2019
1	Biological Therapy 01/2018
1	Nutrition Therapy (Medical Nutrition Therapy) 01/2017
1	Aftercare (After-Treatment) 01/2017
1	Off-Label Use 01/2017
1	Immunotherapy 09/2013
1	Stem Cell Transplantation 08/2011